The Venom System and Envenomation
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Neutralizing effects of polyvalent antivenom on severe inflammatory response induced by Mesobuthus eupeus scorpion venom
This study evaluated the effects of Mesobuthus eupeus (Me) scorpion venom on inflammatory response following injection. Additionally, the present study examined whether immunotherapy at specific time intervals would be effective on inflammatory response after Me venom inoculation. Animals were divided randomly into four groups: the first group received LD50 of venom and the second and third gro...
متن کاملBiochemical and Histopathological study of Mesobuthus eupeus scorpion venom in the experimental rabbits
In tropical and subtropical countries, envenomation by scorpions (so-called scorpionism) represents a serious public health problem. In the present study, the toxic effects of mice LD50 injections of Mesobuthus eupeus (Me) venom on the kidney and liver of anesthetized rabbits were investigated. Six rabbits were selected and ALT, AST, BUN and creatinine were measured at 0, 1 and 3 hours after...
متن کاملHemiscorpius lepturus envenomation: Manifestations and management with specific antivenom
Scorpionism is a known significant problem of medical and social importance in many tropical and subtropical regions including the Middle East. In Iran, highest prevalence of scorpion sting about 60% of all the stings has been reported from Khuzestan province. Among the 21,000 cases of reported scorpion stung patients, 12% were caused by H. lepturus, but contributed to 95% of all moralities in ...
متن کاملEvaluation of oxidant/antioxidant status in serum of sheep experimentally envenomated with Hemiscorpius lepturus scorpion venom
Scorpion envenomation is a main general health problem in developing countries, especially in tropical and subtropical regions. Hemiscorpius lepturus as a member of the Hemiscorpiidae family is cause of the most scorpion sting lethality in Iran. In the present study, the oxidative stress and antioxidant defense in serum of envenomated sheep with the venom of Hemiscorpius lepturus</...
متن کاملInhibition of Nephrotoxic Activity of Mesobuthus Eupeus Scorpion Venom by Commercial Polyvalent Antivenom in Rabbits
Background: Immunotherapy is the only specific treatment for scorpion envenomation. In the present study, the protective effects of polyvalent antivenom against histopathological complications in kidneys and marker changes (BUN and creatinine) induced by Mesobuthus eupeus (Me) scorpion venom was investigated in anesthetized rabbits. Methods: Twenty four rabbits were randomized into four gro...
متن کاملSerum Enzymes Studies in Scorpion (Hemiscorpius lepturus) Dose Related Envenomation in Rabbits
Hemiscorpius lepturus is medically important scorpion species present in the south and southwest part of Iran, causing morbidity and mortality in children and adults. Unlike other scorpions studied so far, the venom of H. lepturus is highly cytotoxic, that can be a reason for its complexity in clinical manifestations in patients stung by this scorpion. Scarce studies showed the mechanism invol...
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